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cGMP Cell Culture
 

Meridian Biologics has over 20 years of cell culture expertise and utilizes this experience for contract Research and Development activities and the production of Biopharmaceutical products under cGMPs. Meridian Biologics cell culture capabilities are as follows:

Manufacturing Services cGMP Size and Number of
Bioreactors/Fermentors
Total Liter Capacity		 Expansion Plans;
List # of Tanks and Size		 Types of Products Produced
Mammalian Cell Culture Y Total Capacity in L = 100 WAVE ®
Bioreactor and 10X10 Stack Cell Factory 		Up to 500L WAVE and/or 4x40CF Stack Viral vaccines, viral challenge stocks, viral vectored gene therapy, and recombinant proteins.
Insect Cell Culture Y Total Capacity in L = 100 WAVE ®
Bioreactor and 10X10 Stack Cell Factory 		Up to 500L WAVE and/or 4x40CF Stack Recombinant proteins including antigens and virus like particles for a vaccine.

Meridian Biologics ancillary biomanufacturing services include:

Cell Banking Meridian Biologics has a great deal of experience producing master and working cell banks. All of the cells used in the production of MLS’ OEM antigens have had master and working cell banks created. Cell banks manufactured by MLS include:
• Mammalian: VERO, FrHK, Hela, and various hybridoma cell lines.
• Insect: Master and Working Cell Banks of insect Sf9 cells for our work on the PVB19 vaccine for the NIH.
  Facilities and equipment for cell banking includes:
           -    multi-use facility can be configured to meet your needs;
           -    separate rooms for uninfected and infected cultures;
           -    controlled-rate freezer; and
           -    vapor phase liquid nitrogen storage system.
Viral Banks Meridian Life Science has 20 years of live virus production experience. MLS has produced master viral banks for baculovirus, Vaccinia, Cytomegalovirus (CMV), Epstein-Barr (EBV), Hepatitis A (HAV), Herpes Simplex (HSV) Type I and II, Measles (Rubeola), Mumps, Respiratory Syncytial (RSV), Rotavirus, Rubella (German Measles), and Varicella-Zoster Virus (VZV), and others.
Cell Culture Equipment:
• Shaker flask.
• Cell-line or culture flask.
• Roller bottle (0.5 to 1.5 smooth or ridged, up to 1,500 bottles are processed weekly for production of Rubella antigen).
• Spinner flask (Up to 30 Liter Spinner flask).
• Roller bottle (0.5 to 1.5 smooth or ridged, up to 1,500 bottles are processed weekly for production of Rubella antigen).
• Cell Factories: Up to 40 CF10 stacks.
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